English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Emerging evidence supports roles of enhancer RNAs (eRNAs) in regulating target gene. Here, we study eRNA regulation and function during skeletal myoblast differentiation. We provide a panoramic view of enhancer transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA production. Super enhancer (se) generated  seRNA-1  and  -2  promote myogenic differentiation in vitro and in vivo.  seRNA-1  regulates expression levels of two nearby genes, myoglobin ( Mb ) and apolipoprotein L6 ( Apol6 ), by binding to heterogeneous nuclear ribonucleoprotein L (hnRNPL). A CAAA tract on  seRNA-1  is essential in mediating  seRNA-1 /hnRNPL binding and function. Disruption of  seRNA-1 -hnRNPL interaction attenuates Pol II and H3K36me3 deposition at the  Mb  locus, in coincidence with the reduction of its transcription. Furthermore, analyses of hnRNPL binding transcriptome-wide reveal its association with eRNAs is a general phenomenon in multiple cells. Collectively, we propose that eRNA-hnRNPL interaction represents a mechanism contributing to target mRNA activation.

MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation