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It is assumed that intracellular pathogenic bacteria have to cope with DNA alkylating stress within host cells. Here we use single-cell reporter systems to show that the pathogen  Brucella abortus  does encounter alkylating stress during the first hours of macrophage infection. Genes encoding direct repair and base-excision repair pathways are required by  B. abortus  to face this stress in vitro and in a mouse infection model. Among these genes,  ogt  is found to be under the control of the conserved cell-cycle transcription factor GcrA. Our results highlight that the control of DNA repair in  B. abortus  displays distinct features that are not present in model organisms such as  Escherichia coli .

Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus