English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The mechanisms behind carbon dioxide (CO 2 ) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the  Staphylococcus aureus mpsAB  operon, known to play a role in membrane potential generation, is crucial for growth at atmospheric CO 2  levels. The genes  mpsAB  can complement an  Escherichia coli  carbonic anhydrase (CA) mutant, and CA from  E. coli  can complement the  S. aureus  delta- mpsABC  mutant. In comparison with the wild type,  S. aureus mps  mutants produce less hemolytic toxin and are less virulent in animal models of infection. Homologs of  mpsA  and  mpsB  are widespread among bacteria and are often found adjacent to each other on the genome. We propose that MpsAB represents a dissolved inorganic carbon transporter, or bicarbonate concentrating system, possibly acting as a sodium bicarbonate cotransporter.

MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels