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It is widely assumed that inositol trisphosphate (IP 3 ) and ryanodine (Ry) receptors share the same Ca 2+  pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP 3 - and Ry-receptors are associated with two functionally distinct intracellular Ca 2+  stores, respectively. While the IP 3 -sensitive Ca 2+  store refilling requires Orai2 channels, Ry-sensitive Ca 2+  store refilling involves voltage-gated Ca 2+  channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.

Two types of functionally distinct Ca2+ stores in hippocampal neurons