English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes remains elusive. We observed maternally expressed, imprinted lncRNA  H19  increased upon cold-activation and decreased in obesity in BAT. Inverse correlations of  H19  with BMI were also observed in humans.  H19  overexpression promoted, while silencing of  H19  impaired adipogenesis, oxidative metabolism and mitochondrial respiration in brown but not white adipocytes. In vivo,  H19  overexpression protected against DIO, improved insulin sensitivity and mitochondrial biogenesis, whereas fat  H19  loss sensitized towards HFD weight gains. Strikingly, paternally expressed genes (PEG) were largely absent from BAT and we demonstrated that  H19  recruits PEG-inactivating  H19 -MBD1 complexes and acts as BAT-selective PEG gatekeeper. This has implications for our understanding how monoallelic gene expression affects metabolism in rodents and, potentially, humans.

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat