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Aromatic polyesters are widely used plastics currently produced from petroleum. Here we engineer  Escherichia coli  strains for the production of aromatic polyesters from glucose by one-step fermentation. When the  Clostridium difficile  isocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase (HadA) and evolved polyhydroxyalkanoate (PHA) synthase genes are overexpressed in a  d -phenyllactate-producing strain, poly(52.3 mol% 3-hydroxybutyrate (3HB)- co -47.7 mol%  d -phenyllactate) can be produced from glucose and sodium 3HB. Also, various poly(3HB- co - d -phenyllactate) polymers having 11.0, 15.8, 20.0, 70.8, and 84.5 mol% of  d -phenyllactate are produced from glucose as a sole carbon source by additional expression of  Ralstonia eutropha  β-ketothiolase ( phaA ) and reductase ( phaB ) genes. Fed-batch culture of this engineered strain produces 13.9 g l −1  of poly(61.9 mol% 3HB- co- 38.1 mol%  d -phenyllactate). Furthermore, different aromatic polyesters containing  d -mandelate and  d- 3-hydroxy-3-phenylpropionate are produced from glucose when feeding the corresponding monomers. The engineered bacterial system will be useful for one-step fermentative production of aromatic polyesters from renewable resources.

One-step fermentative production of aromatic polyesters from glucose by metabolically engineered Escherichia coli strains