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Pulse transit time (PTT), which refers to the travel time between two arterial sites within the same cardiac cycle, has been developed as a novel cuffless form of continuous blood pressure (BP) monitoring. The aim of this study was to investigate differences in BP parameters, including BP variability, between those assessed by beat-to-beat PTT-estimated BP (eBP BTB ) and those assessed by intermittent PTT-estimated BP at fixed time intervals (eBP INT ) in patients suspected of having sleep disordered breathing (SDB). In 330 patients with SDB (average age, 66.8 ± 11.9 years; 3% oxygen desaturation index [ODI], 21.0 ± 15.0/h) from 8 institutes, PTT-estimated BP was continuously recorded during the nighttime. The average systolic eBP BTB , maximum systolic and diastolic eBP BTB , standard deviation (SD) of systolic and diastolic eBP BTB , and coefficient variation (CV) of systolic and diastolic eBP BTB  were higher than the respective values of eBP INT  (all  P  &lt; 0.05). Bland–Altman analysis showed a close agreement between eBP BTB  and eBP INT  in average systolic BP and SD and CV of systolic BP, while there were disagreements in both minimum and maximum values of eBP BTB  and eBP INT  in patients with high systolic BP ( P  &lt; 0.05). Although systolic BP variability incrementally increased according to the tertiles of 3%ODI in both eBP BTB  and eBP INT  (all  P  &lt; 0.05), there was no difference in this tendency between eBP BTB  and eBP INT . In patients with suspected SDB, the difference between eBP BTB  and eBP INT  was minimal, and there were disagreements regarding both the minimum and maximum BP. However, there were agreements in regard to the index of BP variability between eBP BTB  and eBP INT .

Pulse transit time-estimated blood pressure: a comparison of beat-to-beat and intermittent measurement