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Disruptions in redox balance lead to oxidative stress, a promoter of morbidity in critical illness. This study aimed to: (1) characterize the plasma and alveolar thiol/disulfide redox pools, (2) examine their associations with alveolar macrophage phagocytosis, and (3) determine the effect of high dose vitamin D 3 on plasma thiol/disulfide redox.

Oxidative stress in critically ill ventilated adults: effects of vitamin D3 and associations with alveolar macrophage function