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Circular RNAs (circRNAs) play important roles in cancer tumorigenesis and progression, representing prognostic biomarkers and therapeutic targets. In this case, we demonstrated the role of  circ-NOLC1  in epithelial ovarian cancer (EOC). Our results have shown that  Circ-NOLC1  expression was higher in EOC tissues than in normal tissues, and was positively associated with FIGO stage, differentiation. Among ovarian cancer cell lines,  circ-NOLC1  expression was the highest in A2780, and lowest in CAOV3. Overexpression of  circ-NOLC1  in CAOV3 cells increased cell proliferation, migration, and invasion ability, whereas silencing of  circ-NOLC1  in A2780 cells had the opposite effect: however, neither  circ-NOLC1  downregulation nor overexpression influenced  NOLC1  mRNA expression. In nude mice with subcutaneous tumors,  circ-NOLC1  downregulation decreased tumor growth. Bioinformatic analysis and RNA-binding protein immunoprecipitation showed that  circ-NOLC1  could bind to ESRP1. In addition, the overexpression of  circ-NOLC1  significantly increased ESRP1, RhoA, and CDK1 protein and mRNA expression level;  circ-NOLC1  downregulation had the opposite effects. The tumor-promoting effect of  circ-NOLC1  was inhibited by knockdown of ESRP1, CDK1, or RhoA expression in  circ-NOLC1 -overexpressing cells, which might act by modulating RhoA and CDK1 expression. In conclusion, our study demonstrated that  Circ-NOLC1  might promote EOC tumorigenesis and development by binding ESRP1 and modulating CDK1 and RhoA expression.

Circ-NOLC1 promotes epithelial ovarian cancer tumorigenesis and progression by binding ESRP1 and modulating CDK1 and RhoA expression