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Increasing evidence suggest that lncRNAs (long noncoding RNAs) play important roles in human cancer. Breast cancer is a heterogeneous disease and the potential involvement of lncRNAs in breast cancer remains unexplored. In this study, we characterized a novel lncRNA,  RP1-5O6.5  (termed as  RP1 ). We found that  RP1  was highly expressed in breast cancer and predicted poor prognosis of breast cancer patients. Gain-of-function and loss-of-function assays showed that  RP1  promoted the proliferation and metastasis of breast cancer cells in vitro and in vivo. Mechanistically,  RP1  maintained the EMT and stemness states of breast cancer cells via repressing p27kip1 protein expression.  RP1  combined with the complex p-4E-BP1/eIF4E to prevent eIF4E from interacting with eIF4G, therefore attenuating the translational efficiency of p27kip1 mRNA. Furthermore, we found that p27kip1 evidently downregulated Snail1 but not ZEB1 to inhibit invasion of breast cancer cells. Kruppel-like factor 5 (KLF5) was positively correlated with  RP1  in breast cancer tissues. Moreover, we demonstrated that KLF5 recruited p300 to the  RP1  promoter to enhance  RP1  expression. Taken together, our findings demonstrated that KLF5-regulated  RP1  plays an oncogenic role in breast cancer by suppressing p27kip1, providing support for the clinical investigation of therapeutic approaches focusing on  RP1 .

KLF5 regulated lncRNA RP1 promotes the growth and metastasis of breast cancer via repressing p27kip1 translation