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Recent studies suggest important roles for long non-coding RNAs as essential regulators of myogenic differentiation. Here, we report that lncRNA  Irm  is upregulated during myogenesis. Functional analyses show that the overexpression of  Irm  enhances myogenic differentiation, whereas the inhibition of  Irm  has completely opposite effects in vitro. Notably, the inhibition of  Irm  blocks damage-induced muscle regeneration in vivo. Mechanistically,  Irm  regulates the expression of myogenic genes by directly binding to MEF2D, which in turn promotes the assembly of MyoD/MEF2D on the regulatory elements of target genes. Collectively, we have identified a novel lncRNA that interacts with MEF2D to regulate myogenesis.

Long non-coding RNA Irm enhances myogenic differentiation by interacting with MEF2D