English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Helicobacter pylori  has coexisted with humans for approximately 60,000 years and greater than 50% of the global population is infected with  H. pylori .  H. pylori  was successfully cultured in vitro in 1983 and studies of  H. pylori  have achieved substantial advances over the last 35 years. Since then,  H. pylori  has been characterized as the primary pathogenic factor for chronic gastritis, peptic ulcer, and gastric malignancy. Numerous patients have received  H. pylori  eradication treatment, but only 1–2% of  H. pylori -infected individuals ultimately develop gastric cancer. Recently, numerous epidemiological and basic experimental studies suggested a role for chronic  H. pylori  infection in protecting against inflammatory bowel disease (IBD) by inducing systematic immune tolerance and suppressing inflammatory responses. Here we summarize the current research progress on the association between  H. pylori  and IBD, and further describe the detailed molecular mechanism underlying  H. pylori -induced dendritic cells (DCs) with the tolerogenic phenotype and immunosuppressive regulatory T cells (Tregs). Based on the potential protective role of  H. pylori  infection on IBD, we suggest that the interaction between  H. pylori  and the host is complicated, and  H. pylori  eradication treatment should be administered with caution, especially for children and young adults.

Helicobacter pylori infection and inflammatory bowel disease: a crosstalk between upper and lower digestive tract