English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Long noncoding RNAs (lncRNAs) are emerging as key regulators of crucial cellular processes. However, the molecular mechanisms of many lncRNA functions remain uncharacterized.  Sox2ot  is an evolutionarily conserved lncRNA that transcriptionally overlaps the pluripotency gene  Sox2 , which maintains the stemness of embryonic stem cells and tissue-specific stem cells. Here, we show that  Sox2ot  is expressed in the developing mouse cerebral cortex, where it represses neural progenitor (NP) proliferation and promotes neuronal differentiation.  Sox2ot  negatively regulates self-renewal of neural stem cells, and is predominately expressed in the nucleus and inhibits Sox2 levels.  Sox2ot  forms a physical interaction with a multifunctional transcriptional regulator YY1, which binds several CpG islands in the  Sox2  locus in a  Sox2ot -dependent manner. Similar to  Sox2ot , YY1 represses NP expansion in vivo. These results demonstrate a regulatory role of  Sox2ot  in promoting cortical neurogenesis, possibly by repressing  Sox2  expression in NPs, through interacting with YY1.

Long noncoding RNA Sox2ot and transcription factor YY1 co-regulate the differentiation of cortical neural progenitors by repressing Sox2