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The role of pre-existing donor-specific anti-human leukocyte antigen antibodies (HLADSA) in hematopoietic cell transplantation (HCT) is the subject of much debate, reflecting the increasing feasibility of successful transplantation across HLA mismatch barriers. In our study of patients transplanted for non-malignant disease (NMD), HLA-mismatching increased the risk of graft failure and was 2 to 3 fold higher for the compared to patients with malignancies.1 After adjustment for other factors, the odds ratio for primary or

Donor-specific anti-HLA antibodies in unrelated hematopoietic cell transplantation for non-malignant disorders