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The relationship between peripheral oxygen saturation (SpO 2 ) and the inspired oxygen concentration is non-linear. SpO 2 is frequently used as a dichotomized predictor, to manage this non-linearity. We propose the saturation virtual shunt (VS) as a transformation of SpO 2 to a continuous linear variable to improve interpretation of disease severity within clinical prediction models.

A transformation of oxygen saturation (the saturation virtual shunt) to improve clinical prediction model calibration and interpretation