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Background  The rates of severe or Class III obesity (BMI ≥ 40.0 kg/m 2 ) and endometrial cancer (EC) incidence and mortality have been increasing significantly in the United States. Adults with severe obesity are more likely to die and women with severe obesity have a higher risk of EC development and mortality than those with Class I/II obesity (BMI: 30–<40 kg/m 2 ). However, no prior studies have evaluated the neural response to food cues by obesity severity/class in adults with or without cancer.    Methods  We conducted a functional magnetic resonance imaging visual food cue task in 85 obese Stage I EC survivors who were seeking weight loss in a lifestyle intervention at baseline. We evaluated the neural response to high-calorie vs. non-food images after an overnight fast (fasted state) and after eating a standardized meal (fed state), and grouped patients by obesity class (Class I/II:  n  = 38; Class III:  n  = 47).    Results  In the fasted state, we found increased activation in several regions including the dorsolateral prefrontal cortex (DLPFC) in Class III and Class I/II patients (whole brain cluster corrected (WBCC),  p  < 0.05), which was significantly higher in Class III vs. Class I/II ( p  < 0.05). We found decreased activation in the insula in the fasted state, which was significantly lower in Class I/II vs. Class III ( p  = 0.03). In the fed state, we found increased activation in the DLPFC in Class III and Class I/II (WBCC,  p  < 0.05). The increased activation in cognitive control/inhibition regions (DLPFC) is consistent with the summative literature; however, the decreased activation in taste information processing regions (insula) was unexpected.    Conclusions  Our results provide novel insights on food cue response between different classes of obesity and highlight the importance of targeting the DLPFC in weight loss interventions, particularly in severely obese patients. Additional studies examining food-related neural circuitry between different classes of obesity are needed.

nutrition and diabetes

Insights to the neural response to food cues in class III compared with class I and II obese adults using a sample of endometrial cancer survivors seeking weight loss