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Hypoxic-ischemic (HI) encephalopathy causes mortality and severe morbidity in neonates. Treatments with a therapeutic window &gt;6 h are currently not available. Here, we explored whether delayed transplantation of allogenic neural stem cells (NSCs) at 10 d after HI could be a tool to repair HI brain injury and improve behavioral impairments.

pediatric research

Delayed administration of neural stem cells after hypoxia–ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice