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Genome-wide association studies have identified rs314276, rs314263, rs7759938, and rs314280 in or near the LIN28B gene as associated with age at menarche. To date, the effect of polymorphisms in this gene on idiopathic central precocious puberty (ICPP) in Chinese girls have not been reported. The aim of this study was to evaluate the association of the four loci with ICPP in Chinese girls.

Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls