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Objective: Early detection of late onset sepsis (LOS) in the NICU is hindered by the fact that suspicious symptoms are often late and nonspecific while many laboratory adjuvant tests have a poor early sensitivity. A mathematical algorithm (RALIS #1, Integralis Ltd Israel) using six routine clinical parameters measured every two hours (Body temperature, Heart Rate, Respiratory Rate, Episodes of Bradycardia and Oxygen Desaturation, Body weight) has been developed to allow for early detection of LOS.

Early Detection of Late-Onset Sepsis in Very Low Birth Weight Infants