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The influenza virus has proved an elusive target in the development of broadly protective vaccines. A new study identifies an antibody with broad neutralizing activity against influenza viruses of different subtypes. The antibody recognizes a highly conserved region on the viral hemagglutinin that may be targeted to prevent infection. Influenza viruses remain a significant cause of morbidity and mortality worldwide. Circulating virus strains demonstrate a dramatic increase in resistance to available drugs, making the development of new treatments, both prophylactic and therapeutic, a priority.

Universal epitopes of influenza virus hemagglutinins?