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Eukaryotic RNA, including both ribosomal RNA and tRNA, is more heavily modified post-transcriptionally than bacterial RNA, and it had been suggested that these differences facilitate the discrimination of self and non-self by the immune system. In agreement with this idea, two studies now reveal that 2′-O-methylation of G18 (Gm18) on bacterial tRNA suppresses activation of the immune response.

Gm18, a bacterial 'invisibility cloak'