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Background: The role of glucocorticoids in body fluid control is full of controversy. It is well documented that glucocorticoids could produce potent and persistent diuresis in congestive heart failure. But, the diuretic effect was not reported in patients with euvolemia.&#xd;&#xa;Objective: To test the hypothesis that the diuresis induced by glucocorticoids is systemic volume dependent. &#xd;&#xa;Methods: The diuretic effect of glucocorticoids in rats with various systemic volume statuses (i.e. systemic volume depletion, euvolemia, and systemic volume overload, respectively) was recorded. &#xd;&#xa;Results: Glucocorticoids only produced potent and persistent diuresis in the rats with systemic volume overload.&#xd;&#xa;Conclusion: The diuresis induced by glucocorticoids was systemic volume dependent, which explained the phenomenon that glucocorticoids only have potent and persistent diuretic effect in congestive heart failure.  &#xd;&#xa

Why Do Glucocorticoids Produce Potent and Persistent Diuresis Only in Subjects with Volume Overload Other Than Euvolemia