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Delayed type hypersensitivity to natural rubber latex is rare compared to IgE mediated immediate reactions. Binding of allergens to MHC Class II is a crucial step in the presentation of antigens to CD4+ T Cells responsible for delayed reactions. Computational prediction of MHC class II epitopes on thirteen known latex allergens using SMM-align method revealed strong binding with several alleles. This shows that latex allergens are capable of initiating delayed type hypersensitivity in susceptible individuals. N at ur e P re ce di ng s : h dl :1 01 01 /n pr e. 20 09 .2 93 1. 1 : P os te d 6 M ar 2 00 9

Delayed-Type hypersensitivity to latex: Computational prediction of MHC class II epitopes on latex allergens