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Selective COX-2 and COX-1 inhibitors were administered (i.p. acutely) to normal and parkinsonian rats, followed by the analysis of the striatal dopamine, GABA and glutamate concentrations using the microdialysis technique, simultaneously, the catalepsy of animals was evaluated . Selective COX-2 inhibition showed improving effects on the catalepsy followed by decreasing the striatum glutamatergic GABAergic and enhancing the dopaminergic neurotransmission. In addition histological studies showed that COX inhibition had not any improving effects on damaged SNc neurons.

COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission