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In the Nature 7 June issue, researchers from the Welcome Trust Case Control Consortium (WTCCC) reported the findings of a large genome-wide association (GWA) study of 14,000 cases of common diseases and 3000 controls studies revealing the role of several loci in the genetic risk of common diseases. &#xd;&#xa;&#xd;&#xa;We wish to emphasize that by making public the access to databases, consortia allow other investigators to search for association between candidate genes and T2D-related phenotypes. As an example we found, in a pilot study enrolling 1100 individuals that SNPs in the CLOCK (i.e. rs1554483 and rs6843722) were associated with hypertension (p value &#x3c; 0.01, and 0.01, respectively). Interestingly, the same association was found by the WTCCC study (rs1554483, rs4580704, rs6843722 and rs4864548 with p&#x3c;0.039, 0.014, 0.049 and 0.019). However, these findings were not mentioned by the authors because of the stringent p value criteria logically used by them in the face of a WGA

Genome-wide scanning versus candidate gene approach in the genetic architecture of common diseases.