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Mounting clinical and preclinical work implicates the endocannabinoid (eCB) system as a prominent regulator of drug reinforcement (Parsons and Hurd, 2015). Specifically, the cannabinoid type 1 (CB1) receptor has emerged as a major conduit by which addictive drugs access brain reward circuits to exploit reinforcement mechanisms and motivate drug abuse processes.

Endocannabinoid Regulation of Cocaine Reinforcement: an Upper or Downer?