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The likelihood to develop stress-related psychiatric disorders in response to childhood trauma exposure may be moderated by the individual’s genetic predisposition (Manuck and McCaffery, 2014). One of the genetic variants reported to alter the risk for psychiatric disorders following childhood trauma is a functional variant in FKBP5, a gene encoding a co-chaperone of the glucocorticoid receptor (GR).

FKBP5 Allele-Specific Epigenetic Modification in Gene by Environment Interaction