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Common variant genome-wide association studies (GWASs) have, to date, identified &gt;24 risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS comparing 6,476 PD cases with 302,042 controls, followed by a meta-analysis with a recent study of over 13,000 PD cases and 95,000 controls at 9,830 overlapping variants. We then tested 35 loci (P &lt; 1 × 10 -6 ) in a replication cohort of 5,851 cases and 5,866 controls. We identified 17 novel risk loci (P &lt; 5 × 10 -8 ) in a joint analysis of 26,035 cases and 403,190 controls. We used a neurocentric strategy to assign candidate risk genes to the loci. We identified protein-altering or cis-expression quantitative trait locus (cis-eQTL) variants in linkage disequilibrium with the index variant in 29 of the 41 PD loci. These results indicate a key role for autophagy and lysosomal biology in PD risk, and suggest potential new drug targets for PD.

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci