English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Th17 and regulatory T (T reg ) cells are integral in maintaining immune homeostasis and Th17–T reg  imbalance is associated with inflammatory immunosuppression in cancer. Here we show that Th17 cells are a source of tumour-induced Foxp3 +  cells. In addition to natural (n)T reg  and induced (i)T reg  cells that develop from naive precursors, suppressive IL-17A + Foxp3 +  and ex-Th17 Foxp3 +  cells are converted from IL-17A + Foxp3 neg  cells in tumour-bearing mice. Metabolic phenotyping of Foxp3-expressing IL-17A + , ex-Th17 and iT reg  cells demonstrates the dissociation between the metabolic fitness and the suppressive function of Foxp3-expressing T reg  cell subsets. Although all Foxp3-expressing subsets are immunosuppressive, glycolysis is a prominent metabolic pathway exerted only by IL-17A + Foxp3 +  cells. Transcriptome analysis and flow cytometry of IL-17A + Foxp3 +  cells indicate that Folr4, GARP, Itgb8, Pglyrp1, Il1rl1, Itgae, TIGIT and ICOS are Th17-to-T reg  cell transdifferentiation-associated markers. Tumour-associated Th17-to-T reg  cell conversion identified here provides insights for targeting the dynamism of Th17–T reg  cells in cancer immunotherapy.

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells