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The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with  P  combined <3 × 10 −8 ): 1q42.2 (rs12129938 in  PCNXL2 ), 3q26.2 (rs6793295 a missense mutation in  LRCC34  near  TERC ), 5q22.1 (rs73227498 between  NREP  and  EPB41L4A ), 10q24.33 (rs7902587 near  OBFC1 ), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in  SMAD3 ). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the  TERT  gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10 −7 ) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.

A genome-wide association study yields five novel thyroid cancer risk loci