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The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical development. In  draxin  −/−  mice, thalamocortical axons do not enter the neocortex. This phenotype is sufficiently rescued by the transgenic expression of  draxin  in neocortical neurons. Genetic interaction data suggest that draxin acts through Deleted in colorectal cancer (DCC) and Neogenin (Neo1), to regulate thalamocortical projections  in vivo . Draxin promotes the outgrowth of thalamic axons  in vitro  and this effect is abolished in thalamic neurons from  Dcc  and  Neo1  double mutants. These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors.

Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex