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Thyroid hormone deficiency and excess have long been associated with mood- and anxiety-related disorders. Adjuvant treatment with high doses of thyroid hormone has been used effectively to treat mood disorders in the absence of peripheral thyroid disease,1, 2 suggesting that aberrant central, but not necessarily peripheral, thyroid hormone levels relate to the symptoms.

Parent-of-origin allelic contributions to deiodinase-3 expression elicit localized hyperthyroid milieu in the hippocampus