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Variants in the monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT) genes, related to decreased clearance of catecholamines, were associated with an increased hypothalamo–pituitary–adrenal axis response to a social stressor.1 The aim of the present study was to replicate this finding. Replication of genetic associations is essential before conclusions and causal interpretations can be drawn.

Genetically based reduced MAOA and COMT functioning is associated with the cortisol stress response: a replication study