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H-magnetic resonance spectroscopy at 3T permits quantitative determination of the glutamate (Glu) concentration in human hippocampus. Typical position of single hippocampal voxel is illustrated in (a). (b) and (c) PRESS spectra obtained from hippocampal voxels show that hippocampal glutamate (yellow) and N-acetly-aspartate (blue) concentrations are influenced by diurnal cortisol levels. For more information on this topic, please refer to the article by Colla et al. on pages 696–704. Molecular Psychiatry (2009) 14, 647 & 2009 Nature Publishing Group All rights reserved 1359-4184/09 $32.00

MR spectroscopy at 3T to detect stress effects on hippocampal glutamate