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regulatory loop. Cell Cycle 2009; 8: 1966–1967. 15 Attar EC, Johnson JL, Amrein PC, Lozanski G, Wadleigh M, DeAngelo DJ et al. Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502. J Clin Oncol 2013; 31: 923–929. 16 Liu S, Liu Z, Xie Z, Pang J, Yu J, Lehmann E et al. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-κB– dependent DNA methyltransferase activity in acute myeloid leukemia. Blood 2008; 111: 2364–2373. 17 Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V et al. A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment. J Clin Invest 2007; 117: 99–111.

CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS