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New sequencing technologies are facilitating the development of large panels of genes that can be screened for mutations in patients with suspected hematological malignancies. Emerging evidence, however, has indicated that some malignancy-associated mutations are detectable in the general population, raising questions about the utility of broad mutation screening of peripheral blood or bone marrow DNA as a diagnostic tool.

Detection of leukemia-associated mutations in peripheral blood DNA of hematologically normal elderly individuals