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Classical Hodgkin lymphoma (HL) is a common lymphoid malignancy that displays unique features with respect to morphology, tumor biology and clinical presentation. Histologically, classical HL is characterized by large mononuclear Hodgkin and multinucleated Reed–Sternberg (HRS) cells.

The IL-15 cytokine system provides growth and survival signals in Hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells