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In 10 patients with malignant gliomas, the intracerebral distribution of [ 99m Tc]–hexamethylpropyleneamine oxime ([ 99m Tc]–HM-PAO) was studied with single photon emission computed tomography (SPECT) in comparison with C 15 O 2  steady-state inhalation technique to measure cerebral blood flow using positron emission tomography (PET). In all instances, the cerebral [ 99m Tc]–HM-PAO distribution was comparable with the regional pattern of cerebral blood flow (rCBF) observed with PET. This was confirmed by a significant correlation of tumor to cortex and tumor to white matter ratios between these two experimental methods. However, the contrast between high and low activity regions in the SPECT scans was significantly less than that in the PET scans. Contrast enhancement of the SPECT scans was accomplished using a correction formula proposed by Lassen.

journal of cerebral blood flow and metabolism

Tomographic Studies of rCBF with [99mTc]-HM-PAO SPECT in Patients with Brain Tumors: Comparison with C15O2 Continuous Inhalation Technique and PET