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Investigation of the bioactive metabolites from the soil-derived actinomycete, Streptomyces sp. HS-HY-071, a new furan-type antibiotic, HS071 (1), was isolated. Its structure was established as methyl 4-hydroxymethyl-2-pentylfuran-3-carboxylate on the basis of extensive 1D and 2D NMR and MS spectral analysis. It exhibited in vitro activity against HCT-116 cell with an IC50 of 18.2 microg/ml.

HS071, A New Furan-type Cytotoxic Metabolite from Streptomyces sp. HS-HY-071