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Although reducing energy density (ED) enhances weight loss, it is unclear whether all dietary strategies that reduce ED are comparable, hindering effective ED guidelines for obesity treatment. This study examined how changes in number of low-energy-dense (LED) (&lt;4.186 kJ/1.0 kcal g -1 ) and high-energy-dense (HED) (&gt;12.56 kJ/3.0 kcal g -1 ) foods consumed affected dietary ED and weight loss within an 18-month weight loss trial.

Increasing low-energy-dense foods and decreasing high-energy-dense foods differently influence weight loss trial outcomes