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The clinical, angiographic, ultrastructural and immunohistochemical features of a bilateral and asymmetrical case of Coats' disease in a three year old girl are described. The left eye showed advanced disease and was enucleated. Pathological examination revealed an exudative vasculopathy with ultrastructural evidence of interendothelial cell separation and formation of fenestrations. An isolated vascular malformation was discovered in the right eye. This was successfully treated with Argon laser under general anaesthesia.

Bilateral Coats' disease in an infant (a clinical, angiographic, light and electron microscopic study)