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Urea breath test (UBT), as a leading preferred non-invasive diagnostic technology, but may not be able to detect oral  H. pylori . With negative results of UBT, the patient may have an oral infection. On the basis of the fact of success, eradication rate may increase by 21% in the 95% Cl range after the elimination of oral  H. pylori, the  author believes oral  H. pylori  does exist and the oral cavity is the second colonized site aside its primary site of the stomach.  H. pylori  migrated out of Africa along with its human host  circa  60 000 years ago; they are not lives in stomach only. In this review article, evidence established in recent years studies with use more appropriate technology had been listed and discussed. The author considers the oral cavity is a black hole for  H. pylori  infection that significant effective on gastroenterology and another medical field. The role of the oral cavity as the source of  H. pylori  infection is so controvert in past years. It seems like a human being having a second-time face to discover  H. pylori  in the history.

Are the view of Helicobacter pylori colonized in the oral cavity an illusion?