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The effects of cell-growth regulating agents of apolipoprotein(a) (apo(a)) synthesis were examined in human hepatocarcinoma cell lines. Among four cell lines, apo(a) can be detected in three cell lines, SK-HEP-1, Hep 3B and Chang cells, but can not be detected in Hep G2 cells at the same protein concentration. Particularly, SK-HEP-1 cells synthesized the highest level among the examined cell lines. Two cell lines, SK-HEP-1 and Hep 3B cells were treated with several cell-growth regulating agents; dimethyl sulfoxide, a l l - t r a n s retinoic acid, interleukin-6, phorbol 12-myristate 13- acetate (PMA) and sodium butyrate. Culture media were harvested to determine the apo(a) level which was produced from these cells. Dimethyl sulfoxide and retinoic acid inhibited apo(a) synthesis dose- dependently. In both cell lines, maximum inhi- bitions induced by dimethyl sulfoxide and retinoic acid were observed at 2.0% and 2.0 M, respec- tively. PMA increased apo(a) synthesis in both cell lines. Interleukin-6 suppressed apo(a) synthesis in dose-dependent manner and completely blocked at 2,000 U/ml in Hep 3B cells, while there was no changes in SK-HEP-1 cells.

Inhibition of apo(a) synthesis by several cell-growth regulating agents in two human hepatocarcinoma cell lines, SK-HEP-1 and Hep 3B cells