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Recently, Houlle et al reported results of two modifier SNPs in Lynch syndrome, rs16892766 on 8q23.3 and rs3802842 on 11q23.1 previously identified as low-susceptibility colorectal cancer (CRC) loci, challenging earlier reported findings. In 2009 Wijnen et al demonstrated that two SNPs located on 8q23.3 (rs16892766) and 11q23.1 (rs3802842) were associated with an increased risk of developing CRC in Dutch Lynch syndrome patients. The study revealed that patients’ homozygote for SNP rs16892766 were associated with an elevated risk of CRC in a dose-dependent manner with a 2.16-fold increased risk of developing CRC, whereas the variant (CC) genotype of SNP rs3802842 was associated with an increased risk of CRC in female carriers only (HR=3.08). In a combined analysis of the two SNPs, the risk was significantly associated with the number of risk alleles and the effect was shown to be stronger in female carriers than in male carriers

8q23.3 and 11q23.1 as modifying loci influencing the risk for CRC in Lynch syndrome