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Although previous studies reported that calcium supplementation can effectively improve bone mineral density in postmenopausal women, some studies showed the reverse conclusion. One of the reasons was that most of the studies did not take into full consideration the information of noncompliers, which seriously influenced the precision of conclusion. The aim of this paper was to investigate the effect of calcium supplementation on bone mineral density with correcting impact of noncompliance using the complier average causal effect (CACE).

european journal of clinical nutrition

Estimating the causal effect of milk powder supplementation on bone mineral density: a randomized controlled trial with both non-compliance and loss to follow-up