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Our previous reports have shown that laminin-glycopeptides (LN-GPs), the total glycopeptides prepared from laminin (LN), can prevent the experimental lung metastasis and liver metastasis of mouse cancer cells. In order to explore the anti-metastatic mechanism of LN-GPs, we studied the effects of LN-GPs on metastasis-related behaviors of cancer cells in vitro. LN-GPs did not affect cell survival. However, LN-GPs inhibited cell attachment and spreading of S180 cells on LN- and Matrigel-substrate in dose-dependent and time-dependent manners. Moreover, inhibition of cell attachment and spreading on Matrigel substrates were much greater on Matrigel substrate than on LN substrate. In the presence of LN-GPs, S180 cells on LN substrate changed from a flattened polygonal shape to a round one, the migration of S180 cells on LN substrate decreased, and the number of a highly invasive human pulmonary giant carcinoma PG cells invading Matrigel filter in a Boyden chamber was reduced. LN-GPs thus have multiple inhibitory effects on cancer metastasis-related behaviors.

Effects of laminin glycopeptides on metastasis-related behaviors of cancer cells