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Recent studies have furthered our understanding of the function of long noncoding RNAs (lncRNAs) in numerous biological processes, including cancer. This study investigated the expression of a novel lncRNA, colorectal neoplasia differentially expressed ( CRNDE ), in colorectal carcinoma (CRC) tissues and cells by real-time RT-PCR and  in situ  hybridization, and its biological function using a series of  in vitro  and  in vivo  experiments to determine its potential as a prognostic marker and therapeutic target.  CRNDE  was found to be upregulated in primary CRC tissues and cells ( P <0.05), and the upregulation of  CRNDE  expression is a powerful predictor of advanced TNM stage ( P <0.05) and poor prognosis for CRC patients ( P =0.002). The promoting effects of  CRNDE  on the cell proliferation, cell cycling and metastasis of CRC cells were confirmed both  in vitro  and  in vivo  by gain-of-function and loss-of-function experiments. Mechanistically, it was demonstrated that  CRNDE  could form a functional complex with heterogeneous nuclear ribonucleoprotein U-like 2 protein (hnRNPUL2) and direct the transport of hnRNPUL2 between the nucleus and cytoplasm. hnRNPUL2 that was accumulated in the cytoplasm could interact with  CRNDE  both physically and functionally, increasing the stability of  CRNDE  RNA. Moreover, gene expression profile data showed that  CRNDE  depletion in cells downregulated a series of genes involved in the Ras/mitogen-activated protein kinase signaling pathways. Collectively, these findings provide novel insights into the function and mechanism of lncRNA  CRNDE  in the pathogenesis of CRC and highlight its potential as a therapeutic target for CRC intervention.

cell death and disease

Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways