English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Current hypothesis suggest that tumors can originate from adult cells after a process of 'reprogramming' driven by genetic and\udepigenetic alterations. These cancer cells, called cancer stem cells (CSCs), are responsible for the tumor growth and metastases.\udTo date, the research effort has been directed to the identification, isolation and manipulation of this cell population. Independently\udof whether tumors were triggered by a reprogramming of gene expression or seeded by stem cells, their energetic metabolism is\udaltered compared with a normal cell, resulting in a high aerobic glycolytic 'Warburg' phenotype and dysregulation of mitochondrial\udactivity. This metabolic alteration is intricately linked to cancer progression.The aim of this work has been to demonstrate the\udpossibility of differentiating a neoplastic cell toward different germ layer lineages, by evaluating the morphological, metabolic and\udfunctional changes occurring in this process. The cellular differentiation reported in this study brings to different conclusions from\udthose present in the current literature. We demonstrate that 'in vitro' neuroblastoma cancer cells (chosen as experimental model)\udare able to differentiate directly into osteoblastic (by rapamycin, an mTOR inhibitor) and hepatic lineage without an intermediate\ud'stem' cell step. This process seems owing to a synergy among few master molecules, metabolic changes and scaffold presence\udacting in a concerted way to control the cell fate

Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor