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Apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism.\udAs statins induce the translocation of cytosolic Bax to the\udmitochondria and allow to permeabilize the mitochondrial\udouter membrane during apoptosis, further studies will be\udcarried out on the expression of proapoptotic genes, such as\udBax or Bcl2.\udThese findings, even if obtained in an SH-SY5Y undifferentiated\udcell line, surely represent a first step towards the\udunderstanding of the neuronal damage caused by inflammation\udprocesses in MA

Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line