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The past 25 years of research has brought us close to understanding the apoptotic form of programmed cell death, a major regulatory mechanism that shapes us during embryogenesis and keeps us properly functional and healthy on a daily basis. We know that mistakes in regulating this process contribute to various human diseases ranging from cancer, autoimmunity, immunodeficiency to neurodegenerative diseases, and we now have novel drugs targeting apoptosis-regulatory molecules in development or at hand. Some of these compounds have entered clinical trials and might be beneficial in curing diseases such as cancer, particularly in combination with other classical therapeutics.

The apoptotic pore on mitochondria: are we breaking through or still stuck?